Unlocked all character bios
Completed the game on Human difficulty
Defeated Carnage
Damaged Carnage with fire at least 3 times before defeating him
Destroyed 20 body armors
Defeated Green Goblin
Defeated Electro
Defeated Kingpin
Acquired the ionic web
Defeated Kraven
Defeated Black Cat
Defeated Cletus Kasady
Defeated 100 enemies
Heroism to the maximum
Acquired the Seismic Blast ability
Defeated Shocker
Completed all photo challenges
Defeated 50 enemies by performing stealth takedowns
Photographed all Cletus Kasady symbols
Disarmed 50 enemies
Completed the game on Hero difficulty
Unlocked all suits
Completed all hideouts
Completed all combat challenges
Achieved 30 multidodges
Achieved 100 critical hits
Completed the game on Super Hero difficulty
Defeated 300 enemies
Defeated 500 enemies
Saved 50 civilians
Reached maximum levels for all suits
Unlocked all concept art
Completed 10 deadlock situations
Completed 10 building on fire situations
Completed 10 rescue situations
Completed 10 petty crime situations
Collected all Spider-Man comic books
Completed 5 races
Performed 50 signature moves
Destroyed any armored enemy using Web-Strike
Completed a hideout without being spotted
Retrieved all parts of Black Cat's journal
Retrieved all parts of Menken's journal
Retrieved all parts of Detective's journal
Achieved a combo streak of 42
Performed 15 signature moves