Unlock all Trophies
Unlock all concept art
Collect all audio evidence
Collect all magazines
Complete all XTreme Race challenges
Complete all XTreme Video challenges
Clear all car chases
Complete the game on super hero difficulty
Complete the game on hero difficulty
Complete the game on human difficulty
Defeat Lizard
Defeat Nattie
Defeat 1000 enemies
Rescue Alistaire Smythe
Defeat the S-03
Collect all hidden Tech Pieces
Collect all Oscorp Manuals
Acquire all upgrades
Rescue all infected civilians
Resolve all police deadlocks
Complete all Oscorp Secret Research Labs
Clear the second fight against the Hunter robots
Return all escapees to the police
Defeat Felicia
Defeat Scorpion in the city
Immobilize 6 enemies simultaneously with web
Perform a Web-Rush punch
Defeat Rhino in the sewers
Defeat 500 enemies
Defeat the S-02
Defeat Scorpion in quarantine
Defeat 100 enemies by performing Stealth Takedowns
Collect all 700 Spider-Man Comic Pages
Defeat Iguana
Destroy a Seeker before it can call a Hunter
Clear the first fight against the Hunter robots
Defeat a Hunter without using your Web-Shooters
Defeat Vermin
Defeat 50 enemies by performing Stealth Takedowns
Defeat 100 enemies
Perform 25 Signature Moves
Defeat Rhino in the city
Save a hostage caught in a petty crime
Achieve a combo streak of 42
Defeat the S-01 without touching the ground
Defeat the S-01
Chain 10 Web-Rushes in the city