Unlock all Trophies
Defeat the S-01 without touching the ground
Unlock all concept art
Clear all car chases
Complete all XTreme Race challenges
Complete all XTreme Video challenges
Complete the game on super hero difficulty
Complete the game on hero difficulty
Complete the game on human difficulty
Defeat Lizard
Collect all magazines
Collect all audio evidence
Defeat Nattie
Rescue Alistaire Smythe
Defeat the S-03
Collect all hidden Tech Pieces
Collect all Oscorp Manuals
Acquire all upgrades
Complete all Oscorp Secret Research Labs
Resolve all police deadlocks
Rescue all infected civilians
Clear the second fight against the Hunter robots
Defeat Felicia
Defeat 1000 enemies
Return all escapees to the police
Chain 10 Web-Rushes in the city
Immobilize 6 enemies simultaneously with web
Collect all 700 Spider-Man Comic Pages
Defeat Scorpion in the city
Perform a Web-Rush punch
Defeat Rhino in the sewers
Defeat 500 enemies
Defeat the S-02
Defeat Scorpion in quarantine
Defeat 100 enemies by performing Stealth Takedowns
Achieve a combo streak of 42
Defeat Iguana
Destroy a Seeker before it can call a Hunter
Clear the first fight against the Hunter robots
Defeat a Hunter without using your Web-Shooters
Defeat Vermin
Defeat 50 enemies by performing Stealth Takedowns
Defeat 100 enemies
Defeat Rhino in the city
Save a hostage caught in a petty crime
Perform 25 Signature Moves
Defeat the S-01