Complete all CHALLENGES for "Jailhouse Judgment"
Complete all Director's Cut levels in Hardcore Mode
Complete all CHALLENGES for "Naked Terror"
Complete all CHALLENGES for "Creeping Flesh"
Complete all CHALLENGES for "Scream Train"
Complete all CHALLENGES for "Papa's Palace of Pain"
Complete all levels in Director's Cut
Maintain a Goregasm for 2 minutes
Complete any level in Director's Cut without using any continues
Collect 17 comic book pages
Complete any level with the targeting crosshair off
Complete a level without triggering an enforced reload (i.e. reaching zero bullets)
Achieve a Goregasm
Complete all levels in Story Mode
Collect 15 posters
Collect 10 LPs
Complete "Jailhouse Judgment" in Story Mode
Complete "The Fetid Waters" in Story Mode
Complete "Scream Train" in Story Mode
Collect 15 figurines
Buy a new weapon
Complete "Creeping Flesh" in Story Mode
Kill 5 or more mutants with one grenade
Complete "Carny" in Story Mode
Complete "Ballistic Trauma" in Story Mode
Decapitate 200 mutants
Fully upgrade any weapon
Complete "Naked Terror" in Story Mode
Complete any level with only one health segment remaining
Complete "Papa's Palace of Pain" in Story Mode
Kill 100 mutants "Gangster Style" (holding gun sideways)
Play each minigame through to completion once
Complete all CHALLENGES for "The Fetid Waters"
Complete all CHALLENGES for "Carny"
Complete all CHALLENGES for "Overkill"
Complete all CHALLENGES for "Ballistic Trauma"
Unlock all unlockables and purchase all weapons
Achieve an S rank for all levels in Story Mode or Director's Cut
Complete all levels in Classic Mode without using any continues
Unlock all trophies