Complete all levels in Story Mode
Complete "Jailhouse Judgment" in Story Mode
Buy a new weapon
Complete a level without triggering an enforced reload (i.e. reaching zero bullets)
Complete "The Fetid Waters" in Story Mode
Decapitate 200 mutants
Complete "Scream Train" in Story Mode
Collect 15 figurines
Complete "Creeping Flesh" in Story Mode
Collect 10 LPs
Fully upgrade any weapon
Complete "Carny" in Story Mode
Kill 5 or more mutants with one grenade
Complete "Ballistic Trauma" in Story Mode
Complete "Naked Terror" in Story Mode
Achieve a Goregasm
Complete "Papa's Palace of Pain" in Story Mode
Play each minigame through to completion once
Unlock all trophies
Maintain a Goregasm for 2 minutes
Collect 15 posters
Collect 17 comic book pages
Kill 100 mutants "Gangster Style" (holding gun sideways)
Complete any level with only one health segment remaining
Complete any level in Director's Cut without using any continues
Complete any level with the targeting crosshair off
Complete all levels in Director's Cut
Complete all CHALLENGES for "Papa's Palace of Pain"
Complete all CHALLENGES for "Naked Terror"
Complete all CHALLENGES for "Ballistic Trauma"
Complete all CHALLENGES for "Carny"
Complete all CHALLENGES for "Creeping Flesh"
Complete all CHALLENGES for "Scream Train"
Complete all CHALLENGES for "The Fetid Waters"
Complete all CHALLENGES for "Jailhouse Judgment"
Complete all CHALLENGES for "Overkill"
Unlock all unlockables and purchase all weapons
Achieve an S rank for all levels in Story Mode or Director's Cut
Complete all levels in Classic Mode without using any continues
Complete all Director's Cut levels in Hardcore Mode